Think at Task Manager (and at a number of other programs that are NOT involved in the booting process AND that are NOT automatically started during the boot process) as a huge number of extremely light balls (think of polistyrene or small air filled balloons).
If you fill the trunk of your car with them, the car won't be slower, nor it will be harder to start on cold mornings.
Surely you cannot put anymore any luggage in the trunk, but that's it, lots of volume but no (noticeable) weight.
The CTRL+ALT+DEL (commonly known as "the three finger salute" or - more technically SAS Secure Attention Sequence) is something that is "embedded" in the NT kernel:
and "trapping" it is intentionally made impossible (or very, very difficult).
In recent Windows versions (unlike the good ol' ones) the CTRL+ALT-DEL should be connected to a menu (and not directly to Task Manager) which can be (within limits) be customized through gpedit settings.
The "direct" shortcut to Task Manager is now CTRL+SHIFT+ESC:
Starting - I believe - with some versions of Windows 10 there is the "Keyboard Filter" feature:
that allows to disable some key combinations, but there is not a method to re-map a key combo to another program, AFAIK/AFAICR .
TMX has an option "Replace Task Manager".
What will that do?
More to try: