I'm going to guess the answer is no, I suppose the BIOS runs in a special mode, and the memory regions it is able to write to/access are protected from outside access (except maybe when flashing). But since it's possible to effectively change the BIOS when flashing, then it seems reasonable to conclude that there must be a way to manipulate BIOS settings without entering it directly, either programmatically or via a script.
No?. Yes?. (provide proof). Maybe?.