I'm sure there is no impact with extents because unity is "clsuter", not sector. But i can be wrong.
For LBA, unity is sector.
So, for LBA in MBR style with disk 4K 512e, i think that the "firmware/controler" inside the disk make the conversion from "normal" sector size(not physical sector size but which name to call the "normal" sector size, "logical size" perhaps). I think, not verify.
For LBA in MBR with disk 4Kn, so big new disk, not usb key, i think no problem because normal and physical sizes are identical.
In GPT disk, i think that the calculation must take care of the "protective MBR sector" if the disk is initialized by a MS program. And also struct is different, so calculation is complex ( i put links to ms info in a previous post).
All above is for basic disk.
For dynamic disk, i think that some extents can be on a physical disk 1 and some others extents can be on an other physical disk 2. But i'm not sure. It's only that i understand when i read MS informations.
I hope you can give more good, better, verified informations.
Ps : i know easy2boot doesn't need to play with these details ( Basic or not, 4K 512n, 4Kn, GPT/MBR ). And i will dead before a USB key comes with GPT and 4Kn !