I guess I should have been clearer with my question. Do official Microsoft ISOs, intended at being used to create Windows To Go drives, contain .esd's?
A refresh media is meant to reset an existing installation, not create a Windows To Go drive, so I don't think that qualifies.
Even if it did, after having looked at it, I'm gonna pass on .esd support. It looks like way too few people would be using in comparison to the effort it would take to add support in Rufus. since .esd are not compatible with the native WIM APIs that Windows provide. So, even as Rufus is a free product (or should I say, even more so because Rufus is a free product) it's simply not cost effective for me to add support for such a feature.
Again, unless you can point me to an official ISO, that contains a .esd, and that is intended by Microsoft to be used as a Windows To Go creation media, I'll have to treat .esd support the same way as I'd treat request to add support for ISOs containing RAR compressed install images: something that would be nice to have, but that only a handful of people might be using when creating custom ISOs and is unlikely to benefit the vast majority of users, who will work with official installation media.